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Filtered Search Results
Medchemexpress LLC mPEG-amine (MW 1000) | 80506-64-5 | 99.2% | (C2H4O)nC3H9NO | 500 MG
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mPEG-amine (MW 1000) is a PEG-based PROTAC linker designed for the synthesis of PROTACs. PROTACs are compounds that connect an E3 ubiquitin ligase ligand with a target protein ligand via a linker. This mechanism exploits the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
- PEG-based PROTAC linker
- Used for the synthesis of PROTACs
- Utilizes ubiquitin-proteasome system
- Selectively degrades target proteins
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Medchemexpress LLC 3,6,9,12,15,18-Hexaoxanonadecan-1-amine | 184357-46-8 | ≥97.0% | 10 G
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m-PEG6-Amine is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. It is also a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins, while ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker.
- PEG-based PROTAC linker
- Cleavable ADC linker
- Used in the synthesis of PROTACs
- Used in the synthesis of antibody-drug conjugates (ADCs)
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Medchemexpress LLC Sulfo DBCO-amine | 2028284-70-8 | 99.00% | 10 MG
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Sulfo DBCO-amine is an alkyl chain-based PROTAC linker utilized in the synthesis of PROTACs. It functions as a click chemistry reagent, possessing a DBCO group capable of undergoing strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing Azide groups. PROTACs operate by exploiting the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
- Alkyl chain-based PROTAC linker
- Used in the synthesis of PROTACs
- Click chemistry reagent
- Contains a DBCO group
- Undergoes strain-promoted alkyne-azide cycloaddition (SPAAC) with azide groups
- Utilizes intracellular ubiquitin-proteasome system to degrade target proteins
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Medchemexpress LLC Amino-PEG6-amine | 76927-70-3 | ≥ 97.0% | 324.41 | 100 MG
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Amino-PEG6-amine is a PEG-based (6 units) PROTAC linker. It can be used in the synthesis of PROTACs, which are molecules that exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins. PROTACs achieve this by containing two different ligands connected by a linker: one ligand binds to an E3 ubiquitin ligase, and the other binds to the target protein.
- PEG-based PROTAC linker
- Used in the synthesis of PROTACs
- Exploits the ubiquitin-proteasome system
- Selectively degrades target proteins
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![eMolecules 104530-79-2 | (S)-Tetrahydrofuran-3-amine | Accela ChemBio (ASD) | MFCD08234425 | 87.122 | C4H9NO | 97.000 | N[C@H]1CCOC1 | 1g | 724424962](https://assets.fishersci.com/TFS-Assets/CCG/product-images/5000474152.jpg-250.jpg)
eMolecules 104530-79-2 | (S)-Tetrahydrofuran-3-amine | Accela ChemBio (ASD) | MFCD08234425 | 87.122 | C4H9NO | 97.000 | N[C@H]1CCOC1 | 1g | 724424962
(S)-Tetrahydrofuran-3-amine | Accela ChemBio (ASD) | 104530-79-2 | MFCD08234425 | 87.122 | C4H9NO | 97.000 | N[C@H]1CCOC1 | 1g | 724424962
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Medchemexpress LLC 5-Bromoisoquinoline | 34784-04-8 | 208.06 | 10 G
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5-Bromoisoquinoline is a biochemical reagent that can be used as a biological material or organic compound for life science related research. It is also described as a synthetic intermediate useful for pharmaceutical synthesis.
- Can be used as a biochemical reagent
- Useful as a biological material or organic compound for life science related research
- Acts as a synthetic intermediate for pharmaceutical synthesis
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Medchemexpress LLC Amino-PEG9-amine | 474082-35-4 | >98% | C20H44N2O9 | 100 MG
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Amino-PEG9-amine is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
- PEG-based linker
- Used in the synthesis of PROTACs
- Exploits intracellular ubiquitin-proteasome system
- Selectively degrades target proteins
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Medchemexpress LLC m-PEG6-Amine | 184357-46-8 | ≥97.0% | 25 G
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m-PEG6-Amine is a PEG-based PROTAC linker primarily used in the synthesis of PROTACs. It also functions as a cleavable ADC linker for the creation of antibody-drug conjugates (ADCs). PROTACs are designed to exploit the intracellular ubiquitin-proteasome system, selectively degrading target proteins by connecting an E3 ubiquitin ligase ligand to a target protein ligand via a linker. ADCs, on the other hand, consist of an antibody attached to a cytotoxin through an ADC linker.
- Functions as a PEG-based PROTAC linker
- Acts as a cleavable ADC linker
- Used in the synthesis of PROTACs
- Applied in the synthesis of antibody-drug conjugates (ADCs)
- Enables selective protein degradation via the ubiquitin-proteasome system (for PROTACs)
- Targets cleavable linkers and PEGs (in vitro)
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Cayman Chemical 8 12isoiPF2aVI1 5lactone
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A racemic mixture of the lactone form of the free acid, 8,12-iso- iPF2α-VI; the free acid is the most abundant F2-iP2 regioisomer measured in the urine of rats treated to induce lipid peroxidation; used as a biomarker for oxidative stress
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Sigma Aldrich Fine Chemicals Biosciences Neurotensin fragment 8 135MG
Neurotensin fragment 8 135MG
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eMolecules 1337882-40-2 | 3-AMINOISOQUINOLINE-8-CARBOXYLIC ACID HCL | MFCD28291832 | 1g
Ambeed | 5-Chloro-2-methyl-3-nitrobenzaldehyde | 250mg | 582614490 | A1234371 | 1613329-99-9 | MFCD28756706 | 199.590 | C8H6ClNO3
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Medchemexpress LLC M-PEG12-amine | 1977493-48-3 | MFCD11041151 | ≥98.0% | 559.69 g/mol | C25H53NO12 | 25 MG
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m-PEG12-amine is a monodisperse polyethylene glycol (PEG) linker bearing a terminal primary amine, used for bioconjugation, PROTAC synthesis, and as a non-cleavable 12-unit PEG spacer for antibody-drug conjugates.
- Monodisperse 12-unit PEG spacer
- Terminal primary amine for conjugation
- Molecular weight 559.69 g/mol
- Molecular formula C25H53NO12
- Purity ≥98.0% (as stated on COA)
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Medchemexpress LLC Azido-PEG10-amine | 912849-73-1 | ≥97.0% | C22H46N4O10 | 1 G
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Azido-PEG10-amine is a PEG-based PROTAC linker utilized in the synthesis of PROTACs. It functions as a click chemistry reagent, containing an Azide group that can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) reactions with molecules possessing Alkyne groups. It can also participate in strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups. PROTACs consist of two different ligands connected by a linker, leveraging the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
- PEG-based PROTAC linker
- Used in the synthesis of PROTACs
- Click chemistry reagent
- Contains an Azide group for CuAAc and SPAAC reactions
- Appearance is colorless to off-white liquid
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TARGETMOL CHEMICALS INC LIQUIRITIGENIN 25MG
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Also available in 5 mg 10 mg 50 mg 100 mg 500 mg 1 mL 10 mM (in DMSO) and bulk. Please contact Fisher for quotes. Liquiritigenin (4'7-Dihydroxyflavanone) a flavonoid aglycone from licorice is a highly selective estrogen receptor (beta) (ER(beta)) agonist. purity: 99%
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Medchemexpress LLC Azido-PEG23-amine | 2172677-19-7 | 99.93% | C48H98N4O23 | 50 MG
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Azido-PEG23-amine is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. It functions as a click chemistry reagent, possessing an azide group that enables various cycloaddition reactions.
- PEG-based PROTAC linker
- Click chemistry reagent
- Contains an azide group
- Undergoes copper-catalyzed azide-alkyne cycloaddition (CuAAc) reaction with alkyne groups
- Participates in strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with DBCO or BCN groups
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